Sexual Dysfunction

Reduced sexual functioning is commonly associated with depression. Sexual dysfunction frequently improves after anti-depressant treatment. Sexual dysfunction has been seen in patients treated with all classes of antidepressants. The use of selective serotonin reuptake inhibitors has, in particular, been shown to be associated with sexual dysfunction.

There are reports that indicate several drugs are clinically useful in the treatment of sexual dysfunction. The lack of control groups in these studies prevents firm conclusions to be drawn.

Three classes of drugs have been used to counteract the sexual dysfunction associated with selective serotonin reuptake inhibitors: serotonin receptor antagonists, a2-adrenergic receptor antagonists and dopaminergic agents. The results from a clinical trial have suggested that oral sildenafil (Viagra) in the treatment of side-effects associated with anti-depressants may be useful. More studies are needed.